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Helium-3 (³He) is a rare and stable isotope of helium with two protons and one neutron, making it lighter than the more common helium-4. It is naturally produced in trace amounts through the decay of tritium and from cosmic ray interactions with the Earth's atmosphere. However, its concentration on Earth is extremely low, making it difficult and expensive to extract. Most of the helium-3 used today comes from nuclear weapons maintenance or tritium decay in nuclear reactors. It is a non-radioactive, non-toxic gas that can be safely handled under standard laboratory conditions.

Helium-3 has garnered significant interest for its potential use in nuclear fusion as a clean and highly efficient energy source. When fused with deuterium, it produces large amounts of energy with minimal radioactive waste, unlike conventional fusion processes. This makes it a promising candidate for future energy solutions. In addition to energy research, helium-3 is used in cryogenics, particularly in dilution refrigerators that operate at extremely low temperatures, and in neutron detection equipment due to its high neutron absorption cross-section. There is growing interest in mining helium-3 from the Moon, where it is more abundant due to solar wind accumulation on the lunar surface.

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Hydroxychloroquine is a medication originally developed to prevent and treat malaria, but it is now more commonly used in the management of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. It works by modulating the immune system and reducing inflammation, which helps control disease symptoms. Hydroxychloroquine is typically administered orally in tablet form, and it is often prescribed for long-term use under medical supervision due to the potential for cumulative side effects. It is generally well-tolerated, but patients require regular eye examinations as the drug can, in rare cases, lead to retinal toxicity.

During the COVID-19 pandemic, hydroxychloroquine gained global attention as a potential treatment option. However, subsequent clinical studies found no significant benefit for COVID-19 patients and highlighted risks such as heart rhythm disturbances, particularly when combined with other medications. Due to these findings, major health organizations, including the World Health Organization (WHO) and the U.S. Food and Drug Administration (FDA), do not recommend its use for COVID-19 outside of clinical trials. Despite the controversy, hydroxychloroquine remains a critical drug in rheumatology when used appropriately.

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